PUBLICATIONS

SELECTED PUBLICATIONS

  1. Nwosu ZC, Giza H, Nassif M, Charlestin V, Menjivar RE, Kim D, Kemp SB, Sajjakulnukit P, Andren A, Zhang Li, Lai WKM, Loveless I, Steele NG, Hu J, Hu B, Wang S, Pasca di Magliano, M, Lyssiotis CA. Multi-dimensional analyses identify genes of high priority for pancreatic cancer research. JCI Insight. 2025;10(4):e174264. PMID: 39774001.
  2. Sinha S, Panda AK, Xavier das Neves R, Nwosu ZC, Xu K, van Beek E, Desai PP, Sindiri S, Chempati S, Remmert K, Gasmi B, Bojmar L, Zambirinis C, Rossi AJ, Ayabe RI, Wach MM, McDonald JD, Ruff SM, Verbus EA, Saif A, Eade AV, Larrain CM, Friedman LR, Gupta S, Ranjan A, Teke ME, Khan TM, Pu T, Sarvestani AL, Ryan CE, Lambdin JT, Luberice K, Gregory SN, Lux SC, Hong H, Luna AJ, Alexander IA, Akmal SR, Rehman SU, Rainey A, Prickett TD, Koparde VN, Sevilla S, Kuhn SA, Chan K, Sun Z, Bubunenko N, Li E, Hannah C, Gaga G, Andresson T, Cam MC, Wu X, Jenkins LM, Blakely AM, Davis JL, Trinchieri G, Singh PK, Yang JC, Pasca di Magliano M, Lyssiotis CA, Yaffe MB, Shevach EM, Hernandez JM. Expression of IMPACT curtails metabolic plasticity and augments NK cell killing to abrogate metastatic growth. Cancer Discovery. 2025. PMID: 40736016.
  3. Li Y, Huang C, Fan W, Hammad S, Géraud C, Berger L, Wang S, Yao Y, Tong C, Rubie C, Feiner LK, Nwosu ZC, Link F, Erdösi P, Piorońska W, Gould K, Meyer C, Feng R, Liu H, Shao C, Sun B, Ding H, Liebe R, Ebert MPA, Weng H, Glanemann M, Gao C, ten Dijke P, Dooley S, Wang S. ECM1 expression in chronic liver disease: regulation by EGF/STAT1 and IFNγ/NRF2 signaling. Journal of Hepatology Reports, 2025;7(8):101423. PMID: 40671832.
  4. Link F, Li Y, Zhao J, Munker S, Fan W, Nwosu ZC, Yao Y, Wang S, Huang C, Liebe R, Hammad S, Liu H, Shao C, Gao C, Sun B, Török NJ, Ding H, Ebert MP, Weng H, Ten Dijke P, Drasdo D, Dooley S, Wang S. ECM1 attenuates hepatic fibrosis by interfering with mediators of latent TGF-β1 activation. Gut. 2025; 74(3):424-439. PMID: 39448254. 
  5. Mbah NE, Myers AL, Sajjakulnukit P, Chung C, Thompson JK, Hong HS, Giza H, Dang D, Nwosu ZC, Shan M, Sweha SR, Maydan DD, Chen B, Zhang L, Magnuson B, Zhu Z, Radyk M, Lavoie B, Yadav VN, Koo I, Patterson AD, Wahl DR, Franchi L, Agnihotri S, Koschmann CJ, Venneti S, Lyssiotis CA. Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma. Nat Commun. 2024;15(1):8983.  PMID: 39419964
  6. Nwosu ZC*, Ward MH*, Sajjakulnukit P*, Poudel P*, Ragulan C, Kasperek S, Radyk M, Sutton D, Menjivar RE, Andren A, Apiz-Saab JJ, Tolstyka Z, Brown K, Lee HJ, Dzierozynski LN, He X, Ps H, Ugras J, Nyamundanda G, Zhang L, Halbrook CJ, Carpenter ES, Shi J, Shriver LP, Patti GJ, Muir A, Pasca di Magliano M, Sadanandam A, Lyssiotis CA. Uridine-derived ribose fuels glucose-restricted pancreatic cancer. Nature. 2023; 618(7963):151-158. PMID: 37198494. [*first authors]
  7. Menjivar RE, Nwosu ZC, Du W, Donahue KL, Hong HS, Espinoza C, Brown K, Velez-Delgado A, Yan W, Lima F, Bischoff A, Kadiyala P, Salas-Escabillas D, Crawford HC, Bednar F, Carpenter E, Zhang Y, Halbrook CJ, Lyssiotis CA, Pasca di Magliano M. Arginase 1 is a key driver of immune suppression in pancreatic cancer. Elife. 2023; 12:e80721. PMID: 36727849.
  8. Bian Y, Li W, Kremer DM, Sajjakulnukit P, Li S, Crespo J, Nwosu ZC, Zhang L, Czerwonka A, Pawłowska A, Xia H, Li J, Liao P, Yu J, Vatan L, Szeliga W, Wei S, Grove S, Liu JR, McLean K, Cieslik M, Chinnaiyan AM, Zgodziński W, Wallner G, Wertel I, Okła K, Kryczek I, Lyssiotis CA, Zou W. Cancer SLC43A2 alters T cell methionine metabolism and histone methylation. Nature. 2020; 585(7824):277-282. PMID: 32879489.
  9. Nwosu ZC, Piorońska W, Battello N, Zimmer AD, Dewidar B, Han M, Pereira S, Blagojevic B, Castven D, Charlestin V, Holenya P, Lochead J, De La Torre C, Gretz N, Sajjakulnukit P, Zhang L, Ward MH, Marquardt JU, di Magliano MP, Lyssiotis CA, Sleeman J, Wölfl S, Ebert MP, Meyer C, Hofmann U, Dooley S. Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance. EBioMedicine. 2020; 54:102699. PMID: 32330875.
  10. Zhang Y, Lazarus J, Steele NG, Yan W, Lee HJ, Nwosu ZC, Halbrook CJ, Menjivar RE, Kemp SB, Sirihorachai VR, Velez-Delgado A, Donahue K, Carpenter ES, Brown KL, Irizarry-Negron V, Nevison AC, Vinta A, Anderson MA, Crawford HC, Lyssiotis CA, Frankel TL, Bednar F, Pasca di Magliano M. Regulatory T-cell depletion alters the tumor microenvironment and accelerates pancreatic carcinogenesis. Cancer Discovery. 2020; 10(3):422-439. PMID: 31911451
  11. Nwosu ZC, Song MG, Pasca di Magliano M, Lyssiotis CA, Kim KE. Nutrient transporters: connecting cancer metabolism to therapeutic opportunities. Oncogene. 2023; 42(10):711-724. PMID: 36739364 (Review).
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